We’re excited to have partnered with the Structural Genomics Consortium (SGC), an international group of researchers using new technologies to drive the discovery of treatments for incurable diseases.
As one of few charities to collaborate with the SGC, we’re propelling the next generation of discoveries forward. We’re funding two research posts within the SGC, focusing specifically on the biology and proteins involved in the development of brain tumours.
The SGC have a long standing interest in the gene ACVR1, which is found to be mutated in around 25% of cases of diffuse midline glioma (previously known as DIPG). When ACVR1 is mutated, it causes over-activation of a protein known as ALK2, which leads to excessive cell division and tumour growth.
The SGC’s previous research has enabled them to target ALK2 as a therapeutic option for another disease. With our support, they are now designing and creating new drugs to block the actions of ALK2, with the ultimate goal of delivering a new treatment for diffuse midline gliomas.
Currently there’s a lack of treatment options for diffuse midline gliomas (formerly known as DIPG) and prognosis for those diagnosed is poor. This research is making headway to change this.
Diffuse midline gliomas are highly aggressive brain tumours found at the base of the brain. They’re the second most common primary, high grade brain tumour in children. This tumour is difficult to treat as the tumour infiltrates healthy brain in a diffuse manner, and therefore makes it hard to determine where the tumour ends and healthy tissue begins. In addition, the location of the tumour in the brainstem also makes the complete removal of diffuse midline gliomas impossible.
Radiation therapy is the standard treatment. However, it’s not a cure and can only temporarily stabilise symptoms. Less than 1% of children diagnosed with a DIPG survive for longer than five years, so it’s of utmost importance to advance research in this tumour type.
This research aims to help children diagnosed with a diffuse midline glioma and their families.
Research is the only way we will discover kinder, more effective treatments and, ultimately, stamp out brain tumours – for good! However, brain tumours are complex and research in to them takes a great deal of time and money.
Across the UK, over 100,000 families are facing the overwhelming diagnosis of a brain tumour and it is only through the generosity of people like you can we continue to help them.
But, by setting up a regular gift – as little as £2 per month - you can ensure that families no longer face this destructive disease.
"I am working toward translating my findings from genetic screens (a type of laboratory test) to find drug targets to treat this devastating disease" - Dr Alex Bullock