The Tessa Jowell BRAIN MATRIX study is pioneering the diagnosis of brain tumours. It focusses on gliomas – the most common primary brain tumour.
The study aims to improve diagnosis by adding DNA sequencing into brain tumour diagnosis. It aims to test the possibility of using existing NHS infrastructure to ensure patients receive a diagnosis within 28 days.
Since December 2020, the study has recruited over 300 patients. It combines whole genome sequencing and imaging with clinical data and patient-reported quality of life. Collecting as much information as possible about a person’s tumour ensures the best diagnosis and treatment.
Researchers have hit several barriers and are calling for improvements in the pathways to brain tumour diagnosis.
Importantly, the study highlights that brain tumour survival rates may be too short for the current timeframes in whole genome sequencing diagnosis pathways.
BRAIN MATRIX results so far
Research presented at the British Neuro-oncology Society (BNOS) conference in July found that the median time to complete the DNA sequencing diagnosis pathway was 404 days (range 124-653).
This length of time is not suitable for those diagnosed with a brain tumour. The most aggressive glioma, a glioblastoma, has a prognosis of 12-15 months – less than the time to receive the DNA sequencing results.
The results from the clinical study so far also highlighted that there needs to be improved reporting of genomic data back to doctors and patients and that those data need to be more accessible.
The work of BRAIN MATRIX also highlights the geographical inequalities in access to whole genome sequencing.
There are seven Genomic Laboratory Hubs in England. These are located in Birmingham, Cambridge, Manchester, London, Bristol and Newcastle. But they are not currently all able to receive and process samples from glioma patients. People living in the devolved nations (Northern Ireland, Scotland and Wales) who are outside of the GMS in England also have limited access.
The urgent need
There is an urgent need to improve the diagnosis and treatment of brain tumours, as these are the biggest cancer killer of children and adults under 40 years old.
Due to the complex nature of a brain tumour, diagnosis and treatment options are limited. And the Tessa Jowell BRAIN MATRIX study is striving to improve this.
Using imaging and DNA sequencing will give researchers and doctors a detailed understanding of a person’s tumour. This will help identify the most targeted treatment option, and it is hoped will fast-track people to suitable clinical trials.
What we will do
Find out more about the BRAIN MATRIX study
Professor Colin Watts
Professor Colin Watts leads the Brain Cancer Program at the University of Birmingham. As a practising neurosurgeon Professor Watts has established a dedicated neurosurgical-oncology research clinic to support clinical trials and collaborative translational research.