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Losartan is a drug commonly used to treat conditions including high blood pressure, heart disease and kidney disease in people with diabetes. You may also hear losartan called by its brand name Cozar®.
NICE do not recommend losartan as a treatment for brain tumours. It is important to speak to your healthcare team before taking any new medications or making changes to your current brain tumour treatment.
There are currently ongoing trials to see if this type of drug could be effective in improving the outcomes of chemotherapy in patients with pancreatic cancer. In pre-clinical trials with mice, scientists discovered that Losartan increased the blood flow within tumours, therefore improving the delivery of chemotherapy.
Losartan is able to cross the blood-brain barrier. A trial was carried out testing the effect of Losartan on rats implanted with glioma cells which appeared to decrease in tumour volume after 30 days compared to those which were not given the drug. Researchers in France began a clinical trial in 2013 “Angiotensin II Receptor Blockers, Steroids and Radiotherapy in Glioblastoma" which has not yet posted results.
Further research is needed.
If you have further questions, need to clarify any of the information on this page, or want to find out more about research and clinical trials, please contact our team:
0808 800 0004 (free from landlines and mobiles)
support@thebraintumourcharity.org
Phone lines open Mon-Fri, 09:00-17:00
clinicaltrials@thebraintumourcharity.org
You can also join our active online community on Facebook - find out more about our groups.
If you need someone to talk to or advice on where to get help, we offer a wide range of inclusive and accessible support services for everyone affected by a brain tumour.