Using nanobiopsy to characterise tumour cells

Sisters Katy and Rebecca lost their dad to a glioblastoma and want you to help fund the nanobiopsy project.

I want to help

Glioblastomas are the most common, and one of the most aggressive types of brain cancer found in adults. The standard treatment involves surgery to remove as much of the tumour as possible, followed by radiotherapy and chemotherapy.

However, the tumour always grows back so we need to understand why these treatments are failing.

What we don't know is whether glioblastoma cells are naturally resistant to treatment or whether treatments cause changes within the cells that make them resistant.

This project is using advanced technology called nanobiopsy to extract tiny samples from living cells without killing them.

Over the course of treatment, the team - led by Dr Lucy Stead at University of Leeds - will be able to take samples to see how the tumour changes.

What impact will this project have?

It's not normally possible to see how glioblastoma cells change during treatment without killing them. This technology - developed by Dr Paolo Actis - will be crucial in comparing treated and untreated cells side-by-side and how they each respond over time and the course of a treatment.

How will my money help?

  • £6 could pay for two nanopipettes - one to sample a cell before treatment, and one for after
  • £60 could pay for an hour on the machine that helps to sort single cells
  • £300 could pay for a special dye that helps us to track individual cells, so they can be retested after treatment
  • £1,135 could pay for a lane on a sequencing machine which will profile 96 single cells in one go

Donate to this project

This grant is for two years and up to a total of £119k. Work started in later 2018.

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