Official title: The WINDOW consortium for glioblastoma: targeting intra- and inter-patient heterogeneity
Lead researcher: Professor Thomas Wurdinger
Where: VU University Medical Centre, Cancer Centre Amsterdam, Netherlands
When: October 2017 - September 2022
Cost: £1.5 million over five years
Research type: Adult, Glioblastoma (High Grade), Academic, Translational
Award Type: Quest for Cures
The failure of singular chemotherapy treatment options could be overcome by using combination therapies, which includes the use of two or more drugs to treat glioblastomas. Combination therapies would let doctors target multiple aspects of the tumour, allowing for more effective treatment regimens.
So far, choosing drug combinations has been done on the basis of trial and error. The aim of the research led by Dr Würdinger is to create a drug database called the Drug Atlas. This database will provide the optimal drug combinations based on a host of factors, including dosage and toxicity. These combinations will be tested on brain tumour samples collected from patients with glioblastomas.
In addition, the combination therapies will be comprised of drugs that are already being used in clinical settings, allowing them to accelerate the findings of this study to clinical trials.
To determine potential drug resistance, the researchers will manipulate the cells to assess if the changes make the cells more susceptible to the drug combinations.
Until now personalised medicine has only looked at differences across patient groups. Our research goes beyond that, focusing on the differences in individual tumours as they develop, letting us detect important characteristics for personalised treatments.
Glioblastomas, the most common and aggressive form of brain cancer, result in poor prognoses for people diagnosed with this tumour. The poor prognoses can be attributed to the composition of the tumour, as glioblastomas are made up of different types of cells. This diverse composition results in the failure of chemotherapeutic and targeted approaches. Despite our improved knowledge regarding the makeup of this tumour type, there remains a lack of effective treatments, making it essential to get new discoveries to the clinic.
This collaborative research programme aims to create a paradigm shift in the management of glioblastomas. The research will take into account the differences within each tumour and among individuals suffering from a glioblastoma. In doing so, this research hopes to improve the survival of people diagnosed with glioblastoma.
Research is the only way we will discover kinder, more effective treatments and, ultimately, stamp out brain tumours – for good! However, brain tumours are complex and research in to them takes a great deal of time and money.
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Professor Thomas Wurdinger
Thomas is a professor at the cancer center of Amsterdam at the Free University (VU) and director of the neuro-oncology research group, which is an integral part of the Amsterdam brain tumor center.