Brain cancer in babies could be successfully treated with targeted drugs instead of chemotherapy, scientists have announced.
As reported across the news outlets today and on ITV.
Their report said the cancer in infants is biologically distinct from other childhood brain tumours, a new study suggests.
The study is believed to be the largest of infant gliomas to date and found that these tumours are molecularly different from those in older children, helping explain why they tend to be less aggressive.
According to researchers, the results could help pick out babies with tumours who could be spared chemotherapy.
Instead, the molecular weaknesses in the tumours could be treated with existing targeted drugs.
Scientists at The Institute of Cancer Research, London (ICR), carried out a large-scale study of 241 infants from around the world diagnosed with glioma brain tumours.
They worked with researchers at the Hopp Children’s Cancer Centre Heidelberg in Germany, the UCL Great Ormond Street Institute of Child Health, and St Jude Children’s Research Hospital in the US.
The researchers found that 130 of the 241 tumour samples had an entirely different genetic make-up from other forms of childhood brain tumours, despite looking highly similar under the microscope.
Chris Jones, professor of paediatric brain tumour biology at the ICR said: “Our study offers the biological evidence to pick out those infants who are likely to have a better outcome from their disease, so these very small children and their families can be spared the harmful effects of chemotherapy.
“We showed that brain tumours in infants have particular genetic weaknesses that could be targeted with existing drugs – and clinical trials are planned to test the benefit of these precision medicines as a first-line treatment in clinical trials as soon as possible.”
The study, published in Cancer Discovery, was funded by charities including the CRIS Cancer Foundation, The Brain Tumour Charity, Children with Cancer UK, Great Ormond Street Hospital Children’s Charity, and Cancer Research UK.