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The Everest Centre

Fast facts

  • Official title: The Everest Centre for Research into Paediatric Low Grade Brain Tumours
  • Lead researcher: Dr David Jones
  • Locations: DKFZ, Heidelberg, Germany; UCL, London, UK; QMUL, London, UK
  • When: August 2017 to July 2022
  • Cost: £5 million over a period of 5 years
  • Research type: Paediatric, Low Grade, Quality of Life

What is it?

Located across three institutions, the Everest Centre for Research into Paediatric Low Grade Brain Tumours is a groundbreaking international research initiative bringing together experts from Germany and the UK. 

Led by Dr David Jones, the research aims to propel our understanding and improve treatment for low grade brain tumours, which can often cause severe long-term health problems and in some cases can be fatal.

The international team will focus on four interrelated streams of research:

1. Determining the origin of low grade brain tumour types 

Key researchers: Dr Tom Jacques, University College London; Dr David Capper, Charité Universitätsmedizin Berlin

Low grade brain tumours can be caused by various changes to an individual's genetic code. The research team will use molecular diagnostics to trace the tumour's 'cell of origin'. This will help create a classification system to enable researchers to better target treatments to the individual's specific alterations.

2. Identifying factors that affect tumour growth 

Key researchers: Dr David Jones, German Cancer Research Centre, Germany; Prof JP Martinez-Barbera, University College London, UK

The growth environment of low grade brain tumours is of great importance, especially as the immune system plays a vital role in regulating tumour growth via what's known as the “oncogene-induced senescence" mechanism. This mechanism suppresses tumour growth and could lead to clinical research into a new form of treatment.

3. Developing low grade brain tumour models and pre-clinical screening 

Key researchers: Prof Denise Sheer, Queen Mary University London, UK; Prof Stephan Pfister, German Cancer Research Centre, Germany

Low grade brain tumours have been notoriously difficult to replicate in the lab. Experts in Heidelberg and London will develop new, more accurate tumour models to test new drugs and drug combinations.

4.Enabling an international clinical trial 

Key researchers: Prof Olaf Witt, German Cancer Research Centre, Germany; Dr Darren Hargrave, Great Ormond Street Hospital, UK. 

As part of this programme, the researchers will work with the European Society for Paediatric Oncology to launch a clinical trial - LOw Grade Glioma In Children (LOGGIC). LOGGIC is the first trial that will evaluate the impact of low grade brain tumours and their treatment in children. This trial will assess the child's quality of life, including visual and neurological function

    Why it is important?

    Low grade brain tumours account for about half of all paediatric brain tumours. Yet they're often neglected in favour of their more malignant counterparts. But the often chronic nature of low grade brain tumours means they can have a lifelong burden for those affected. Symptoms of the tumour, along with the side-effects of treatment, and the constant threat of multiple tumour recurrences over long periods of time, can have a severe, negative effect on quality of life. This must change and Dr Jones's research is helping accelerate progress.

    Who will it help?

    Low grade brain tumours are the most common childhood primary brain tumour. Children with this tumour can go through many rounds of treatment, including surgery, chemotherapy, and radiotherapy. This often has a profound long-term effect on their health and wellbeing.

    This research will help these children and their families by finding tailored treatments that could improve their quality of survival, helping us to halve the harm that brain tumours have.

    Milestones

    Achieved

    • The team have analysed various DNA "tags" that can help accurately distinguish between different types of low grade brain tumours. Through this analysis, they have also discovered a new type of paediatric low grade brain tumour that has the potential to be targeted with drugs.
    • The researchers have outlined why pilocytic astrocytomas, the most common childhood low grade brain tumour, grow relatively slowly. These tumours secrete special molecules into their surrounding that causes them to enter a "hibernation" mode and either stop growing or grow extremely slowly.
    • For the upcoming LOGGIC clinical trial, the team are collaborating with a pharmaceutical company who will provide a drug that targets specific factors in tumour cells.

    Upcoming

    • The research team are going to learn more about the tumour's environment, especially how the tumour interact with different aspects of their environment.
    • They are also going be looking at the pathways that are activates in tumour cells compared to healthy brain cells.
    • The LOGGIC trial will be launched across Europe. This study will collect molecular data on tumours, as well as quality of life information from the study participants.

    The story behind The Everest Centre

    Toby Ritchie was diagnosed with a low grade brain tumour at the age of five. In 2015, his dad – Rob – led a unique and physical demanding challenge – Everest in the Alps – to raise money for The Brain Tumour Charity. The team raised an incredible £3m which has been put towards The Everest Centre.

    We are thrilled that the money raised through Everest in the Alps is being used to establish The Everest Centre. This pioneering research will allow scientists to accelerate progress towards finding more effective treatments for the disease and could be revolutionary in improving the lives of children living with low grade tumours.

    Rob Ritchie

    Research is just one other way your donation can make a difference

    Your donation could help fund the following equipment Dr Jones uses for his research:

    • Pipet: £250
      A tool used in the laboratory to measure and transport accurate volumes of liquid.
    • Gel Chamber: £530
      A device that helps separate pieces of DNA that are different in length.
    • Vortex: £220
      A device used in laboratories to mix small vials.
    • Eppendorf Tube Box: £4
      A box to store small lab equipment.
    • DNA Quantification Device: £1300
      A device used to measure the amount of DNA in small samples.

    Donate today

    Group leader Dr David Jones will be working closely with researchers in both London and Germany. They aim to make new discoveries about low grade brain tumours and translate them into new clinical treatments

    History

    Learn how The Everest Centre became a reality from the point of Toby's diagnosis to the fundraising efforts of Everest in the Alps