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If you're a diagnosed with a brain tumour, one of the treatments your medical team may offer is chemotherapy. This is the use of drugs to destroy tumour cells by disturbing their growth. Chemotherapy can be used as a treatment on its own, or it may be used with or after surgery or radiotherapy.
Chemotherapy is the use of cytotoxic (anti-cancer) drugs that affect the growth of tumour cells by interfering with the way they divide and create copies of themselves.
Chemotherapy acts on all dividing cells, including healthy cells, but healthy cells are able to repair themselves better than tumour cells, so fewer of them die after treatment.
Your health team will carefully consider the best course of treatment for you. This will depend on:
Chemotherapy may be given:
You'll be given chemotherapy in a series of treatments separated by rest periods. One treatment session and rest period is called a 'cycle' and a number of cycles make up the 'course' of treatment.
There are various ways that chemotherapy can be given:
Some chemotherapy drugs can be taken in tablet or capsule form like any other tablet. They're absorbed and carried around your body in the bloodstream to reach the tumour cells.
You'll be able to take the tablets at home, but should take care not to touch them and should wash your hands straight afterwards. You should not crush them, unless you're advised to.
There can be an after-taste to these drugs - chewing flavoured gum afterwards can help to disguise this taste.
As with all medication, tablets should be kept out of the reach of children.
Chemotherapy drugs can be injected into a vein (intravenously) or into the spinal fluid (intrathecally). When given intravenously, they may be given via a drip into the veins over half an hour to a few hours. As with tablets, the drugs are absorbed and carried around your body in the bloodstream to reach the tumour cells.
Chemotherapy drugs are sometimes put inside a polymer wafer and inserted into the brain during surgery. The polymer wafers are made from a biodegradable material so they break down in the body over time.
The wafers gradually dissolve over 2-3 weeks, releasing the chemotherapy drug directly into the brain, getting round the blood-brain barrier. Wafers are used to target cells which couldn't be removed by surgery. You may also hear these implants called Gliadel® wafers.
They're only licensed for high grade gliomas where at least 90% of the tumour has been removed by surgery. Their suitability for use also depends on where the tumour is in your brain.
This is a dome-shaped device that sits underneath the scalp and delivers chemotherapy directly into the cerebrospinal fluid (CSF), the clear fluid within the brain and spinal cord. By doing this, chemotherapy is delivered directly to the brain, which increases its effectiveness.However, giving chemotherapy this way can be complicated and difficult, so doesn't form part of routine treatment for most patients.
Individual treatment plans vary and yours will be carefully planned specifically for you.
Typically a course of treatment may last 6-12 months, consisting of 6-12 cycles. You may have chemotherapy for a few days every few weeks.
Chemotherapy is generally given as an outpatient treatment, which means that you don't have to stay in hospital overnight, although in certain circumstances you will need to. A member of your health team will talk to you about this before you start your treatment.
While you will not need to stay in hospital to receive treatment, if you work, you will need to arrange time off for hospital appointments. Side-effects, such as tiredness and nausea, may mean you need a longer period of time off work.
Our Employment resources provide help and information on how to approach your employer about your diagnosis and how they can support you through this time.
You will be monitored for any changes to the tumour, sometimes during and sometimes following treatment. This can be through the use of scans (MRI and CT scans) to see whether the tumour is shrinking.
You will have check-up appointments following treatment, which will sometimes include scans. These appointments may continue for a number of years after your chemotherapy has finished.
Although treatment plans are carefully developed by healthcare professionals to be as effective as possible while having the fewest risks or side-effects, sometimes chemotherapy may not work. This can be worrying, but just because one treatment hasn’t worked, it doesn’t mean others won’t.
Find out more about what happens when treatment doesn’t work.
Find out more about chemotherapy for adults in the full fact sheet
- including side-effects and links to information about wigs and head coverings.
Find out more about chemotherapy for adults in the full fact sheet - Clear print version, designed to RNIB standards
- includes side-effects and links to information about wigs and head coverings.
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