Surgery in the areas to the rear of the skull, also known as the posterior fossa or cerebellum, can cause long lasting negative effects in children. These effects include loss of muscle tone, memory troubles, unsteadiness, and decreased ability to talk. These effects are collectively known as Cerebellar Mutism Syndrome (CMS) or Posterior Fossa Syndrome.
This research project, led by Mr Mallucci, aims to further understand CMS to ultimately help reduce the number of children effected by CMS and improve the management of this condition. This multi-centre study will recruit 500 children with CMS from across the UK and Scandinavia and assess their clinical and imaging data. In particular this study will:
To accomplish the above aims, blood samples will be taken from children to conduct genetic analyses and assessments such as speech evaluation will also be conducted.
Mr Mallucci will be carrying out a multi-centre study to investigate Cerebellar Mutism Syndrome (CMS), a.k.a. Posterior Fossa Syndrome, a serious and poorly understood late effect resulting from surgical complication. It is seen in up to 25% of children after removing tumours from the very back of the skull, known as the cerebellum.
This study will explore the surgical methods associated with CMS and determine whether some patients are at higher risk of developing CMS in order to enhance treatment and improve quality of life. With a greater understanding of CMS they hope to ultimately prevent and reduce the number of children who have CMS after surgery.
CMS is seen in up to 25% of children after surgery in areas to the rear of the skull. This condition can have major negative impacts on the quality of life of affected children and is frequently associated with permanent, and sometimes devastating, effects. CMS is a poorly understood condition and little is known on how to prevent or treat it. This research project is vital to help us further our understanding of this condition.
This research project could help countless children and young adults who are brain tumour survivors. This projects aims to help both prevent CMS from occurring and improve the management of this condition when it does occur, to improve the quality of life of those affected.
If you have any questions about this, or our other research projects, please contact us on firstname.lastname@example.org
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Mr Conor Mallucci is a Consultant Paediatric Neurosurgeon at Alder Hey Children’s Hospital in Liverpool.