Want to help improve brain tumour care? Take part today

CED (Convection Enhanced Delivery)

Convection Enhanced Delivery (CED) is a relatively new technique for delivering chemotherapy drugs directly into brain (and other) tumours.

CED’s ability to bypass the blood-brain barrier – the membrane that controls which substances can pass from the blood into the brain – has resulted in increasing interest in this technique. This is particularly for high grade tumours that cannot be operated on due to their location, or cannot be removed completely. This includes brain tumours such as DIPG (Diffuse Intrinsic Pontine Glioma) in children.

Join our community on Facebook

Our closed Facebook group is a safe space online to connect with other parents who are affected by brain tumours.

What does CED involve?

CED involves an operation to implant up to 4 very narrow catheters (hollow tubes) into the brain. The chemotherapy drugs are delivered through these, directly into the tumour.

The blood-brain barrier then becomes an advantage, as it helps to keep the drugs within the brain.

In addition, as the drugs do not get into the blood system, the risk of having any of the side-effects associated with chemotherapy, such as hair loss and nausea, is low.

More research is being carried out to improve the technology of the catheters (tubes) and the drugs used. other aspects under review, are using the technique to give other possible treatment agents, such as antibodies and immunotoxins.

CED and DIPG

CED for the treatment of DIPG is receiving interest because the tumour is compact and treatment options are limited. (Surgery to remove the tumour is often not an option, due to the dangers of operating on a critical part of the brain. Standard chemotherapy has been found to be ineffective.)

Standard treatment for DIPG is radiotherapy, but this can cause long-term effects, particularly if given to children under 3 years.
A technique, such as CED, that can avoid some of these effects is therefore creating interest.


If you have further questions, need to clarify any of the information on this page, or want to find out more about research and clinical trials, please contact our team:
Support and Information Services
0808 800 0004 Free from landlines and mobiles
Phone lines open Mon-Fri, 09:00-17:00
A member of our Support & Information Team provides support over the phone to somebody affected by a brain tumour diagnosis

Get support

If you need someone to talk to or advice on where to get help, our Support and Information team is available by phone, email or live-chat.

Share your experiences and help create change

By taking part in our Improving Brain Tumour Care surveys and sharing your experiences, you can help us improve treatment and care for everyone affected by a brain tumour.